A class for storing Allele-Specific Chromatin (ASC) data together with the underlying peak-level chromatin accessibility signal. Inherits from DsAcc.

Slots

counts

List of two matrices: 'ref' (reference-allele read counts) and 'alt' (alternative-allele read counts), each [SNP x sample].

accessibility

Matrix of peak-level ATAC-seq counts [peak x sample]. This is the "total" chromatin accessibility signal, independent of allele. May be a DelayedArray/HDF5Matrix when diskDump = TRUE.

diskDump

Flag indicating whether count data is stored on disk (HDF5) rather than in main memory.

The inherited coord slot is a list holding two GRanges: coord$snps (heterozygous SNP positions, annotated with peakId) and coord$peaks (consensus peak coordinates).

Author

Irem B. GUNDUZ